The aim of the current study was to validate the construct validity of Piri-Muridi Scale (Hassan & Kamal, 2010). For this purpose, the data was collected from 291 individuals including men (n = 154) and women (n = 137). Participants belonged from four provinces of Pakistan; Punjab (n = 110), Azad Kashmir (n = 60), Khyber Pakhtunkhawa (n = 61), and Sindh (n = 60). The analysis was done by using AMOS for the purpose of establishing construct validity of Piri-Muridi scale. The indices of fit, items loading, and squared multiple correlations showed good model fit. Further, convergent validity of Piri-Muridi scale also showed significant positive correlation with Spirituality Index of Well Being (Daaleman, 2004; translated by Manzoor, 2014) and Bonding to God scale (Saleem, 2004). Reliability analysis and internal consistency also revealed satisfactory values. Moreover, province wise comparison of study participants was also analyzed and the findings were discussed in the light of relevant literature. Overall, this study helped to establish a valid and reliable measure for future studies on Piri-Muridi in Pakistan.