In today’s competitive environment, education plays an important role within the system. Moreover, the role of teachers is also very vital as the success of the institution depends upon them. The current study focused to find the relationship of job stress (JS) and employee burnout (EB) of university teachers and how self-efficacy (SI) moderates the relationship among psychological disorder of teachers. The country like Pakistan, where physical resources are poor, salaries are not appropriate, a discipline problem, managerial issues, lack of well-equipped resources are some of the causes of job stress and burnout. Data has been collected from university teachers of Pakistan. SPSS and Warp PLS have been used to test the hypotheses of study in the conceptual model. This paper is concluded with discussions on results implications for management and for university teachers.