International Health Regulations (IHRs 2005) is an important initiative against the spread of zoonotic diseases. It obliges all Member States to legislate and execute laws for ensuring the health security of their citizens. Pakistan is a signatory and has framed rules and laws to protect its citizens against such diseases but it has a long way to go in terms of execution, capacity and implementation. This article reviews the IHRs (2005) and how certain provinces of Pakistan are more vulnerable (like Khyber Pahktunkhwa) than others against the perilous spread of infectious diseases.