In recent years, there has been increasing prominence on materials applications in biomedical areas. This article focuses mainly on the low modulus titanium- based alloys. It discusses the biological bio-compatibility and mechanical properties of titanium alloy TI-27Nb and brings out the overall superiority of low modulus titanium based alloys neglecting the cost effect as because of the health concerns of human being. With the advancement in field of medical and material, it is now a well-known fact that the use of Ti alloys increased tremendously because of its better fundamental properties, like biological compatibility, mechanical compatibility and enhanced wear and corrosion resistance in the human body environment. This paper also narrates the influence of crystal structure, biological biocompatibility, low young modulus effect.