The study aims to analyze anti-polio and religious controversy and its link with polio eradication process. Data is collected from a sample of 200 employees of Health department, UNICEF and WHO through questionnaire. Sample size is allocated using proportionate allocation sampling technique. Chi square test is used to measure the association between dependent and independent variables. The findings of the study reveal a significant association of polio vaccination as un-Islamic, opposition of religious scholars, polio as foreign agenda, suspecting the quality and efficacy of oral polio vaccination and fear of reaction with polio eradication process. Moreover, perceiving polio vaccination rounds as needless and vaccination as overdosing were found to be strongly linked with polio eradication. In light of the findings, it is suggested that anti polio and religious controversies surrounding polio vaccination needs to be intelligently overcome. The study further suggests that for any awareness campaign on media or otherwise, religious scholars may be taken on board along with civil society activists.